Endocrine Abstracts

Duplication of the guanine nucleotide-binding protein beta subunit 3 (GNB3) gene is associated with early-onset obesity in individuals with an unbalanced chromosome translocation. Additionally, a cytosine to thymine (C825T) polymorphism in GNB3 is associated with hypertension, obesity and metabolic syndrome; however, the mechanism of GNB3-related obesity is unknown. We created BAC-transgenic mice that carry an extra copy of the human risk-allele (T) ...